Department of Cardiology, Akershus University Hospital

Current research focus

• Molecular mechanisms involved in cardiac hypertrophy, fibrosis and heart failure
• Cardiac mechanics in elite soccer players
• Left and right ventricular function in patients with obstructive sleep apnea (OSA)
• Dual angiotensin-receptor (ARBB)/neutral endopeptidase (NEP) inhibition (ARNi)
• Volume status monitoring in clinical heart failure

Research projects

Project manager

• Significance of pulmonary monocyte/macrophage system in the pathophysiologic mechanisms of heart failure
• Mechanisms of elevated plasma endothelin-1 levels in heart failure
• Torsional mechanics and LV strains in a large cohort of professional soccer players
• Comprehensive evaluation of cardiac function in patients with obstructive sleep apnea (OSA)
• Dual angiotensin-receptor (ARB)/neutral endopeptidase (NEP) inhibition (ARNi) on cardiac hypertrophy and fibrosis
• Non-invasive impedance-based volume status monitoring in heart failure patients

Collaborator

• Hematopoiesis in mice with heart failure
• Functional significance of CTGF-induced restrictive fibrosis of the heart in endurance training vs. heart failure
• Antihypertrophic effects of CTGF in a transgenic rodent model.