Institute for Experimental Medical Research, Oslo University Hospital Ullevaal

Current research focus

Skeletal muscle fatigue.

Main hypothesis:
Posttranscriptional modifications of proteins participating in the contraction-relaxation cycle is different in isometric and isotonic exercise, and alterations in these modifications contribute to the skeletal dysfunction seen in CHF.

Specific aims/subgoals:
• In normal rats, identify the phosphorylation pattern of regulatory proteins important for contraction in isometric versus isotonic exercise
• Investigate how the modification of the proteins is altered in CHF
• Determine which of these alterations that cause reduced force production and increased fatigue development in CHF muscles
• Identify the signalling cascades that respond differently to exercise in normal and heart failure muscles

Research projects

Collaborator

• Skeletal muscle fatigue mechanisms in rats and humans