Institute for Experimental Medical Research, Oslo University Hospital Ullevaal

Current research focus

The research focus is centered on defective Ca²⁺ handling in heart failure. Projects are centered on genetically manipulated mouse models with altered Ca²⁺ handling properties. The aim is to study heart failure resulting from primary defective Ca²⁺ handling, and to distinguish primary and seconday phenotypic characteristics of dysfunction in heart failure.

Research projects

Project manager

• Mouse models for defective Ca²⁺ handling and SR dysfuntion in the heart and skeletal muscle
• Molecular processes triggered by altered Ca²⁺ cycling and SR dysfunction in heart failure

Supervisor

• Serca2 function in the embryonic heart
• Reduction of Serca2 function in skeletal muscle: effects on muscle function and fatigue development

Collaborator

• Hematopoiesis in mice with heart failure
• The role of SERCA2 in calcium dependent arrhythmias
• Heart failure protein interaction
• Calcium homeostasis and the failing heart
• Identification and modulation of signaling complexes involved in hypertrophy and heart failure
• Spatial homogeneity of cardiomyocyte Ca²⁺ handling and sarcomeric function
• Effect of beta-adrenergic stimulation on Ca2+ wave development in SERCA2 KO mice
• Optimization of gene deletion protocols in mouse models utilizing Mer-Cre-Mer (MCM) technology