Department of Pharmacology, University of Oslo

Current research focus

Study the role of phosphodiesterases and natriuretic peptides in the regulation of inotropic effect of 5-HT4 receptor stimulation in failing and postinfarction myocardium.

Study the role of phosphodiesterases regulating the contractile effects of β-adrenoceptors in normal and failing myocardium.

Research projects

Project manager

• A comparison between the receptor signalling mechanisms coupled to 5-HT4 serotonin receptors and to beta-adrenoceptors in failing myocardium.

Collaborator

• Mechanism of action of 5-HT₄ serotonin receptors in failing myocardium
• Signalling mechanisms for the negative inotropic effect of natriuretic peptides in failing myocardium