Institute for Internal Medicine, Oslo University Hospital Rikshospitalet

Current research focus

n/a

Research projects

Project manager

• Pathophysiological role of inflammatory cytokines in heart failure

Supervisor

• Pathogenic role of the regulatory chemokines CCL19 and CCL21 during pressure overload

Collaborator

• Identification of novel secreted factor by expression profiling of hearts from mice with myocardial failure
• The role of syndecan-4 as a stress-sensor and co-receptor in development of myocardial hypertrophy
• Significance of pulmonary monocyte/macrophage system in the pathophysiologic mechanisms of heart failure
• Notch signaling in atherosclerosis
• Mechanisms of elevated plasma endothelin-1 levels in heart failure
• Functional significance of CTGF-induced restrictive fibrosis of the heart in endurance training vs. heart failure
• Role of myocardial CTGF in the pathophysiologic mechanisms of heart failure
• Chronic pulmonal hypoxia and pulmonary hypertension; Mechanisms involved in transition to right heart failure
• The homeostatic chemokine CXCL13 and its receptor CXCR5 are regulated in experimental and human heart failure, and are involved in cardiac remodelling.
• Generation of transgenic mice with inducible, cardiac-restricted expression of CTGF
• Role of the innate immun system in the development and maintenance of cardiovascular disease
• Role of Neil3 in regulating stem cell recruitment following myocardial infarction