Department of Pharmacology, University of Oslo

Current research focus

Study the role of neurohumoral regulation to modify calcium sensitization of myofilaments in failing rat and human heart. Particular focus is upon the signaling mechanisms mediating regulation of the phosphorylation state of myosin light chain and its contribution to inotropic support in failing myocardium.

Research projects

Project manager

• Effects and mechanisms of prostanoid receptor stimulation in normal and failing myocardium
• Characterisation of human 5-HT7 receptor splice variants

Supervisor

• Preassociation of the 5-HT7 receptor and Gs
• Effects and mechanisms of muscarinic receptor stimulation in failing myocardium

Collaborator

• Effects and mechanisms of muscarinic receptor stimulation in failing myocardium
• Chronic pulmonal hypoxia and pulmonary hypertension; Mechanisms involved in transition to right heart failure