Department of Cardiovascular Medicine, Oslo University Hospital Rikshospitalet

Current research focus

Department of Cardiovascular Medicine, Rikshospitalet

Research projects

Supervisor

• Right catheterisation before and after heart transplant
• Inflammation in heart failure- the importance for development of myocardial dysfunction
• Pathogenic role of the regulatory chemokines CCL19 and CCL21 during pressure overload
• Role of Neil3 in regulating stem cell recruitment following myocardial infarction

Collaborator

• Pathophysiological role of inflammatory cytokines in heart failure
• Inflammatory mediators and endothelial function as markers of prognosis in heart failure and after heart transplantation
• Identification of novel secreted factor by expression profiling of hearts from mice with myocardial failure
• The role of syndecan-4 as a stress-sensor and co-receptor in development of myocardial hypertrophy
• The effect of TNF-alpha antagonists on cardiovascular disease in patients with rheumatoid arthritis and related diseases.
• Involvement of phosphorylation of myosin light chain (MLC) in the inotropic responses to stimulation of Gq coupled receptors
• On the role of myocardial α1-adrenoceptors in clinical situations
• Notch signaling in atherosclerosis
• Neurohormonal activation in stable coronary artery disease
• A comparison between the receptor signalling mechanisms coupled to 5-HT4 serotonin receptors and to beta-adrenoceptors in failing myocardium.
• Crosstalk of cGMP on cAMP signalling systems in cardiomyocytes. A key to modifications of cAMP-dependent receptor functions in failing myocardium?
• Characterization of increased calcium sensitivity in heart muscle as inotropic mechanism for receptor stimulation and for levosimendan.
• Cardiac Troponin T among subjects with type 2 DM
• Role of the innate immun system in the development and maintenance of cardiovascular disease
• A role of retinoic acid in remodelling of the failing heart
• Mitochondrial p66Shc - friend or foe?