Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet

Current research focus

The role of the transmembrane heparan sulphate proteoglycan syndecan-4 in normal and failing hearts

Research projects

Project manager

• Syndecan-4, a transmembranous heparan sulphate proteoglycan, and heart failure
• Pathogenic role of the regulatory chemokines CCL19 and CCL21 during pressure overload
• Role of Neil3 in regulating stem cell recruitment following myocardial infarction

Collaborator

• Pathophysiological role of inflammatory cytokines in heart failure
• Identification and modulation of signaling complexes involved in hypertrophy and heart failure
• The role of syndecan-4 as a stress-sensor and co-receptor in development of myocardial hypertrophy
• Hematopoiesis in mice with heart failure
• Calcium homeostasis and the failing heart
• The homeostatic chemokine CXCL13 and its receptor CXCR5 are regulated in experimental and human heart failure, and are involved in cardiac remodelling.
• Role of the innate immun system in the development and maintenance of cardiovascular disease
• Syndecan-4 and heart failure: regulation and modulation of pathological cardiac hypertrophy by syndecan-4