Department of Cardiology, Oslo University Hospital Rikshospitalet and Department of Medicine, Diakonhjemmet Hospital and Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet

Current research focus

• The role of neurohormones and inflammatory mediators in heart failure (humans, rats, mice)
• The role of alveolar macrophages in heart failure (humans, rats)
• The role of fat tissue in heart failure (human, rats)
• The role of inflammatory mediators in atherosclerosis (humans, mice)

Research projects

Collaborator

• Pathophysiological role of inflammatory cytokines in heart failure
• Identification of novel secreted factor by expression profiling of hearts from mice with myocardial failure
• Changes of expression of the cardiac NKCC in ischemic heart failure
• Notch signaling in atherosclerosis
• Role of the innate immun system in the development and maintenance of cardiovascular disease
• Involvement of GRK3 in the pathophysiologic mechanisms of heart failure
• Mechanisms of elevated plasma endothelin-1 levels in heart failure
• Role of myocardial CTGF in the pathophysiologic mechanisms of heart failure
• Chromogranin A, granins and heart disease
• Impaired glucose tolerance in patients with acute myocardial infarction.
• Pathogenic role of the regulatory chemokines CCL19 and CCL21 during pressure overload