Institute for Experimental Medical Research, Oslo University Hospital Ullevaal

Current research focus

Study how altered control vith intracellular Na⁺ affects cardiomyocyte contractility in heart failure. In particular, the crosstalk and possible colocalisation between the Na⁺/Ca²⁺-exchanger and Na⁺/K⁺-ATPase is adressed.

Research projects

Project manager

• Crosstalk between transport proteins that control intracellular sodium in cardiomyoctyes
• 3D imaging of the dyad
• IP₃ signalling and Ca²⁺-wave development in ventricular cardiomyocytes

Supervisor

• Targeting of Na⁺ transporting proteins determines cardiac contractility and rhythm

Collaborator

• L-type Ca2+ current inhibition for prevention of triggered arrhythmias
• SERCA2-RyR2 interplay underlying triggered arrhythmias
• The connection between membrane potential and contractility is changed in heart failure
• Heart failure protein interaction
• Modelling of excitation-contraction coupling
• Calcium homeostasis and the failing heart
• Identification and modulation of signaling complexes involved in hypertrophy and heart failure