Institute for Experimental Medical Research, Oslo University Hospital Ullevaal

Current research focus

Control of calcium and sodium homeostasis during cardiac excitation-contraction coupling.

Research projects

Project manager

• Calcium homeostasis and the failing heart

Supervisor

• Mechanisms underlying the force-frequency response in normal and failing cardiomyocytes
• Spatial homogeneity of cardiomyocyte Ca²⁺ handling and sarcomeric function

Collaborator

• Electrical remodelling in heart failure
• SERCA2-RyR2 interplay underlying triggered arrhythmias
• Heart failure protein interaction
• Serca2 function in the embryonic heart
• Crosstalk between transport proteins that control intracellular sodium in cardiomyoctyes
• Identification and modulation of signaling complexes involved in hypertrophy and heart failure
• Secretoneurin in cardiac ischemia and heart failure
• The homeostatic chemokine CXCL13 and its receptor CXCR5 are regulated in experimental and human heart failure, and are involved in cardiac remodelling.
• Molecular processes triggered by altered Ca²⁺ cycling and SR dysfunction in heart failure
• Chromogranin A, granins and heart disease
• Exercise training as anti-arrhythmic therapy in heart failure
• L-type Ca2+ current inhibition for prevention of triggered arrhythmias
• Optimization of gene deletion protocols in mouse models utilizing Mer-Cre-Mer (MCM) technology
• Role of Neil3 in regulating stem cell recruitment following myocardial infarction